diff --git a/cf-module-system/cf-module-system-api/src/main/java/com/cf/imes/module/system/enums/ErrorCodeConstants.java b/cf-module-system/cf-module-system-api/src/main/java/com/cf/imes/module/system/enums/ErrorCodeConstants.java
index c1d7cda8a..770384fcb 100644
--- a/cf-module-system/cf-module-system-api/src/main/java/com/cf/imes/module/system/enums/ErrorCodeConstants.java
+++ b/cf-module-system/cf-module-system-api/src/main/java/com/cf/imes/module/system/enums/ErrorCodeConstants.java
@@ -440,6 +440,8 @@ public class ErrorCodeConstants {
     public static final ErrorCode INVOICE_TITLE_NOT_EXISTS_ERROR = new ErrorCode(1_002_043_028, "发票抬头不存在，请先创建发票抬头");
     public static final ErrorCode ORG_INVOICE_PURCHASE_RECORD_UPDATE_NUM_NOT_MATCH_ERROR = new ErrorCode(1_002_043_029, "当前勾选的购买记录中部分可能已开票，请查询后重新勾选提交开票");
     public static final ErrorCode ORG_INVOICE_AGREE_FILE_NULL_ERROR = new ErrorCode(1_002_043_030, "确认开票发票附件不能为空，请上传后再提交");
+    public static final ErrorCode INVOICE_TITLE_ORG_EXISTS_ERROR = new ErrorCode(1_002_043_031, "组织下已存在发票抬头，请刷新后编辑抬头内容");
+    public static final ErrorCode INVOICE_TITLE_TAXPAYERID_EXISTS_ERROR = new ErrorCode(1_002_043_032, "纳税人识别号已存在，请检查");
 
     //=========== 支付相关 1-002-048-000 ============
     public static final ErrorCode PAY_CHANNEL_NOT_SUPPORT = new ErrorCode(1_002_048_000, "暂不支持的支付渠道，请使用其他支付渠道");
diff --git a/cf-module-system/cf-module-system-biz/src/main/java/com/cf/imes/module/system/service/funds/invoice/InvoiceServiceImpl.java b/cf-module-system/cf-module-system-biz/src/main/java/com/cf/imes/module/system/service/funds/invoice/InvoiceServiceImpl.java
index 2ac7b8524..72f4d9394 100644
--- a/cf-module-system/cf-module-system-biz/src/main/java/com/cf/imes/module/system/service/funds/invoice/InvoiceServiceImpl.java
+++ b/cf-module-system/cf-module-system-biz/src/main/java/com/cf/imes/module/system/service/funds/invoice/InvoiceServiceImpl.java
@@ -12,6 +12,7 @@ import com.cf.imes.framework.common.util.Assert.AssertUtils;
 import com.cf.imes.framework.common.util.date.LocalDateTimeUtils;
 import com.cf.imes.framework.common.util.json.JsonUtils;
 import com.cf.imes.framework.common.util.object.BeanUtils;
+import com.cf.imes.framework.mybatis.core.query.LambdaQueryWrapperX;
 import com.cf.imes.framework.security.core.LoginUser;
 import com.cf.imes.framework.security.core.util.SecurityFrameworkUtils;
 import com.cf.imes.module.infra.api.file.FileApi;
@@ -56,6 +57,8 @@ import static com.cf.imes.framework.common.util.json.JsonUtils.zipString;
 import static com.cf.imes.framework.security.core.util.SecurityFrameworkUtils.getUserOrganId;
 import static com.cf.imes.module.system.enums.ErrorCodeConstants.INVOICE_NO_EXIST;
 import static com.cf.imes.module.system.enums.ErrorCodeConstants.INVOICE_TITLE_NOT_EXISTS_ERROR;
+import static com.cf.imes.module.system.enums.ErrorCodeConstants.INVOICE_TITLE_ORG_EXISTS_ERROR;
+import static com.cf.imes.module.system.enums.ErrorCodeConstants.INVOICE_TITLE_TAXPAYERID_EXISTS_ERROR;
 import static com.cf.imes.module.system.enums.ErrorCodeConstants.INVOICING_REJECT_REASON;
 import static com.cf.imes.module.system.enums.ErrorCodeConstants.ORG_INVOICE_AGREE_FILE_NULL_ERROR;
 import static com.cf.imes.module.system.enums.ErrorCodeConstants.ORG_INVOICE_PURCHASE_RECORD_UPDATE_NUM_NOT_MATCH_ERROR;
@@ -96,8 +99,14 @@ public class InvoiceServiceImpl implements InvoiceService {
     @Override
     public void insetInvoiceTitle(InvoiceTitleSaveReqVO reqVO) {
         Long organId = SecurityFrameworkUtils.getUserOrganId();
-        if (reqVO.getId() != null) {
-            validTitleOrg(reqVO.getId(), organId);
+
+        Long id = reqVO.getId();
+
+        // 校验纳税人识别号和组织id是否唯一
+        validOrgAndTaxpayerNo(id, organId, reqVO.getTaxpayerId());
+
+        if (id != null) {
+            validTitleOrg(id, organId);
             // 更新抬头
             InvoiceTitleInfoDO titleInfoDO = BeanUtils.toBean(reqVO, InvoiceTitleInfoDO.class);
             invoiceTitleInfoMapper.updateById(titleInfoDO);
@@ -119,6 +128,29 @@ public class InvoiceServiceImpl implements InvoiceService {
                 .build());
     }
 
+    /**
+     * 校验组织和纳税人识别号唯一
+     *
+     * @param id         发票抬头id
+     * @param organId    组织id
+     * @param taxpayerId 纳税人识别号
+     */
+    private void validOrgAndTaxpayerNo(Long id, Long organId, String taxpayerId) {
+        InvoiceTitleInfoDO exist = invoiceTitleInfoMapper.selectOne(new LambdaQueryWrapperX<InvoiceTitleInfoDO>()
+                .neIfPresent(InvoiceTitleInfoDO::getId, id)
+                .eq(InvoiceTitleInfoDO::getOrganId, organId));
+
+        if (ObjectUtil.isNotNull(exist)) {
+            throw new ServiceException(INVOICE_TITLE_ORG_EXISTS_ERROR);
+        }
+        exist = invoiceTitleInfoMapper.selectOne(new LambdaQueryWrapperX<InvoiceTitleInfoDO>()
+                .neIfPresent(InvoiceTitleInfoDO::getId, id)
+                .eq(InvoiceTitleInfoDO::getTaxpayerId, taxpayerId));
+        if (ObjectUtil.isNotNull(exist)) {
+            throw new ServiceException(INVOICE_TITLE_TAXPAYERID_EXISTS_ERROR);
+        }
+    }
+
     /**
      * 校验抬头组织
      *